Flores medical - multisonic - Inhalation mit Ultraschall

Pulmonary hypertension

Pulmonary hypertension in the ICU can arise from a variety of causes. Persistent high or increased pulmonary artery pressure is often seen after heart surgery and heart transplantations, i.e. interventions involving heart-lung machines. Persistent or transient pulmonary hypertension following pulmonary thrombo-endarterectomie (PEA) may pose therapeutic problems. Patients with chronic pulmonary hypertension (e.g. PAH) may also require intensive care because of progressive or acute right-ventricular de-compensation.

Pulmonary hypertension in children is a function of the underlying disease. Causes include: persistent pulmonary hypertension of the newborn (PPHN), bronchopulmonary dysplasia (BPD), pulmonary hypertension associated with congenital heart defects, idiopathic pulmonary arterial hypertension (iPAH), and hypoxic lung failure.

Several casuistries and studies involving a small number of patients have supported the assumption that inhaled iloprost causes a potent and selective reduction of pulmonary artery pressure in postoperative cardiac surgery patients. The improved pulmonary haemodynamics led to stabilization of blood circulation and partially shorter ventilation times and let the patients do well postoperatively without any complications. Iloprost is considered a good alternative to administration of NO. Aside from the more effective vasodilatation compared to that induced with NO, the results of these studies indicate that inhaled iloprost is well tolerated and easy to use.

Study results published confirm that even clinically instable high-risk patients with PAH may benefit from inhaled iloprost.

Further information on inhaled iloprost as a treatment of various other diseases.